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Multi-target regulatory network and screening of core components of classical traditional Chinese medicine against rheumatoid arthritis

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1280-1287.
3593 times 497 times

ZHU Shanshan ZHOU Junting WU Ting

Rheumatoid arthritis Network pharmacology Core active components GO functional analysis KEGG pathway enrichment analysis Multi-targets
Details
Mechanism of houttuynia cordata aqueous extract inhibiting endotoxin-induced uveitis in rats based on the anti-inflammatory signaling pathways of PI3K, Wnt and NF-κB

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1271-1279.
2603 times 460 times

ZHANG Cheng GAO Chenfei FEI Chunxia QU Fei

Houttuynia cordata aqueous extract Uveitis Inflammatory factor PI3K/AKT/mTOR Wnt/β-catenin NF-κB/MAPK
Details
Mechanism of agiophyllum oligo saccharides in improving type 2 diabetes mellitus related liver injury based on proteomics method

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1261-1270.
2664 times 551 times

ZHANG Zihan ZHANG Xiaojie YANG Yuze YANG Tianshuo XING Dongyang MA Qianqian BAO Shuyin

Agiophyllum oligo saccharides Type 2 diabetes mellitus Liver injury Proteomics
Details
Applications and prospects of transfer learning in rare diseases research

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):986-992.
2040 times 556 times

ZHENG Xueying QIN Guoyou YU Yongfu

Rare diseases Scarce data Transfer learning
Details
Application status and development prospect of digital intelligence technology in the diagnosis and treatment of rare diseases

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):972-985.
2544 times 592 times

YANG Yujie QI Leyuan CAO Yanbo WEN Xiaotian LIU Jicong CHEN Bixiao LIU Yawei HE Guohua TIAN Yu

Rare diseases Digital intelligence Full life-cycle
Details
Application and frontier exploration of retrieval-augmented generation technology in medical artificial intelligence

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):962-971.
2891 times 578 times

JIN Zhe ZOU Jian LI Xiao Lyu Jiaxin HU Zhongxu FENG Da

Large language model Retrieval-augmented generation Hallucination problem Medical information retrieval
Details
Research progress on big-data-driven analysis strategies for imbalanced data of rare events

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):952-961.
2577 times 615 times

ZHOU Jiangjie WANG Yutong FENG Tian MENG Xianglong LIANG Baosheng WANG Shengfeng

Rare events Imbalanced data Data-driven Deep learning
Details
Research progress on artificial intelligence methods and applications for small sample data in medicine

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):938-951.
3235 times 606 times

WANG Longhao QIAN Li WU Yazhou

Small sample data Artificial intelligence methods Medical applications
Details
Research progress on rare real-world data-driven target trial emulation for drug repurposing

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):926-937.
2790 times 603 times

LI Bosheng HUANG Xuan WANG Wenxuan YANG Wenyun YAN Fangrong

Target trial emulation Real-world data Propensity Score Drug repurposing Digital intelligence technology
Details
Perioperative rare adverse reactions discovery: real-world data foundations and methodological advances

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):917-925.
2474 times 581 times

YIN Xuan HUANG Ruijian KONG Siyu ZHOU Jifang

Adverse drug reaction Perioperative Pharmacovigilance Digital and intelligent integration Real-world study Methodology
Details
Design and implementation strategies for rare disease clinical research in the digital intelligence era

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):908-916.
2314 times 565 times

SUN Fengyu CAO Borui CHEN Nana ZHONG Xinwen HOU Yan PENG Zhihang

Rare diseases Clinical research Digital intelligence Artificial intelligence Study design
Details
Rare disease clinical research data collection and management challenges and digital intelligence response strategies

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):897-907.
2209 times 522 times

GUO Jian Gulidanna·Asihaer ZHANG Shuyang

Rare disease Data collection Data management Digital intelligence
Details
Study on the method of using attention mechanism and meta-learning to diagnose autism under small sample multi-omics condition

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):887-896.
2247 times 567 times

WANG Qi XIE Kun LIANG Xuezhi LUO Xiangyang LIU Ying CHEN Wen

Autism diagnosis Attention mechanism Meta learning Small sample Multi-omics data integration
Details
Cognitive trajectories modeling of rare reversion in mild cognitive impairment

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):877-886.
2484 times 626 times

QIN Yao HUO Yanji ZHOU Jing ZHOU Yan HAN Hongjuan CUI Jing YU Hongmei

Mild cognitive impairment Reversion Rare events Functional principal component analysis Multi-state model
Details
Development and validation of an XGBoost-based prediction model for acute liver injury in statin users

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):867-876.
2291 times 601 times

MENG Xianglong YU Yuelin SUN Yexiang SHEN Peng JIANG Zhiqin ZHU Yu YIN Yueqi ZHAN Siyan WANG Shengfeng

Statins Acute liver injury Prediction model XGBoost algorithm Cost-sensitive learning
Details
Association between aldehydes and hyperuricemia based on Bayesian kernel machine regression

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):855-866.
2249 times 587 times

BING Shuang HUANG Ru ZHANG Yiying

Aldehydes Uric acid Hyperuricemia Bayesian kernel machine regression
Details
Mining of adverse reaction signals of amlodipine based on the FAERS database and the construction of a digital and intelligent pharmacovigilance platform

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):846-854.
2651 times 650 times

HU Yanghui QIU Ziyan ZHANG Bingsong

Amlodipine Adverse drug event Signal mining FAERS database Digital intelligent platform
Details
Editorial comments of special issue on rare event research driven by digital intelligence

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):845.
1876 times 537 times

WANG Shengfeng

Editorial Note
Details
Practice and innovation of mathematics experiment and case modeling teaching in traditional Chinese medicine colleges and universities driven by artificial intelligence

Published on Journal of Mathematical Medicine 2025,38(8):636-641.
2039 times 544 times

ZHAO Ying PENG Chunhua YE Hong LIN Rong SHAO Jianhua SUN Jijia

Artificial intelligence Traditional Chinese medicine Advanced mathematics Mathematical experiments Mathematical modeling
Details
Perinatal management of placenta percreta with bladder invasion under multidisciplinary collaborative mode: a case report

Published on Journal of Mathematical Medicine 2025,38(8):629-635.
1716 times 504 times

ZHAO Qian LIU Chang LIU Rong

Placenta percreta Multidisciplinary collaboration Total hysterectomy Bladder repair Arterial thrombosis
Details