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Study and discussion on microbial challenge test for compatibility stability of injections

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1329-1335.
5718 times 983 times

LIU Qianying HUANG Cuiping ZHANG Jixin WANG Yuqing ZHANG Qin ZHANG Na

Clinical compatibility Compatibility stability Microbial challenge Methocarbamol injection
Details
The association of sodium benzoate and the potential risk of benzene contamination in oral liquid preparations

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1321-1328.
4709 times 840 times

SUN Li HUANG Ping ZHANG Rong WU Min

Oral liquid preparations Sodium benzoate Benzene Headspace gas chromatography–mass spectrometry Risk evaluation
Details
Examination and screening of the bacteriostatic efficacy of bacteriostatic agents in Baimai ointment prescriptions

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1314-1320.
4482 times 871 times

MU Jianping XIE Nan TENG Baoxia HE Xiaowen GAO Yuan HE Xiaoying

Baimai ointment Bacteriostatic efficacy Prescription screening Bacteriostatic agent
Details
Commercial specification standards and quality evaluation of Ginseng Radix et Rhizoma Rubra

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1303-1313.
5654 times 975 times

FAN Weixu SUN Baohui HOU Fangjie

Ginseng Radix et Rhizoma Rubra Specifications Grades Quality evaluation
Details
In vitro and in vivo quality consistency evaluation of loxoprofen sodium hot-melt adhesive patch and its reference preparation

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1296-1302.
5281 times 958 times

YANG Yang LIU Hui

Loxoprofen sodium patch In vivo and in vitro evaluation In vitro release In vitro permeation Bioequivalence
Details
Study on the integrated processing technology of Isatidis radix based on response surface method

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1288-1295.
4772 times 914 times

LU Shasha WANG Ning WANG Yumei BAI Zhongjie HE Yuanyuan DAI Wenqian

Isatidis radix Integrated processing and processing of origin Response surface method High performance liquid chromatography
Details
Multi-target regulatory network and screening of core components of classical traditional Chinese medicine against rheumatoid arthritis

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1280-1287.
6922 times 979 times

ZHU Shanshan ZHOU Junting WU Ting

Rheumatoid arthritis Network pharmacology Core active components GO functional analysis KEGG pathway enrichment analysis Multi-targets
Details
Mechanism of houttuynia cordata aqueous extract inhibiting endotoxin-induced uveitis in rats based on the anti-inflammatory signaling pathways of PI3K, Wnt and NF-κB

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1271-1279.
4808 times 879 times

ZHANG Cheng GAO Chenfei FEI Chunxia QU Fei

Houttuynia cordata aqueous extract Uveitis Inflammatory factor PI3K/AKT/mTOR Wnt/β-catenin NF-κB/MAPK
Details
Mechanism of agiophyllum oligo saccharides in improving type 2 diabetes mellitus related liver injury based on proteomics method

Published on Frontiers in Pharmaceutical Sciences 2025,29(8):1261-1270.
4781 times 955 times

ZHANG Zihan ZHANG Xiaojie YANG Yuze YANG Tianshuo XING Dongyang MA Qianqian BAO Shuyin

Agiophyllum oligo saccharides Type 2 diabetes mellitus Liver injury Proteomics
Details
Applications and prospects of transfer learning in rare diseases research

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):986-992.
4157 times 1027 times

ZHENG Xueying QIN Guoyou YU Yongfu

Rare diseases Scarce data Transfer learning
Details
Application status and development prospect of digital intelligence technology in the diagnosis and treatment of rare diseases

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):972-985.
5426 times 1075 times

YANG Yujie QI Leyuan CAO Yanbo WEN Xiaotian LIU Jicong CHEN Bixiao LIU Yawei HE Guohua TIAN Yu

Rare diseases Digital intelligence Full life-cycle
Details
Application and frontier exploration of retrieval-augmented generation technology in medical artificial intelligence

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):962-971.
7179 times 1125 times

JIN Zhe ZOU Jian LI Xiao Lyu Jiaxin HU Zhongxu FENG Da

Large language model Retrieval-augmented generation Hallucination problem Medical information retrieval
Details
Research progress on big-data-driven analysis strategies for imbalanced data of rare events

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):952-961.
4869 times 1082 times

ZHOU Jiangjie WANG Yutong FENG Tian MENG Xianglong LIANG Baosheng WANG Shengfeng

Rare events Imbalanced data Data-driven Deep learning
Details
Research progress on artificial intelligence methods and applications for small sample data in medicine

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):938-951.
6469 times 1169 times

WANG Longhao QIAN Li WU Yazhou

Small sample data Artificial intelligence methods Medical applications
Details
Research progress on rare real-world data-driven target trial emulation for drug repurposing

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):926-937.
5513 times 1137 times

LI Bosheng HUANG Xuan WANG Wenxuan YANG Wenyun YAN Fangrong

Target trial emulation Real-world data Propensity Score Drug repurposing Digital intelligence technology
Details
Perioperative rare adverse reactions discovery: real-world data foundations and methodological advances

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):917-925.
4859 times 1089 times

YIN Xuan HUANG Ruijian KONG Siyu ZHOU Jifang

Adverse drug reaction Perioperative Pharmacovigilance Digital and intelligent integration Real-world study Methodology
Details
Design and implementation strategies for rare disease clinical research in the digital intelligence era

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):908-916.
4512 times 1061 times

SUN Fengyu CAO Borui CHEN Nana ZHONG Xinwen HOU Yan PENG Zhihang

Rare diseases Clinical research Digital intelligence Artificial intelligence Study design
Details
Rare disease clinical research data collection and management challenges and digital intelligence response strategies

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):897-907.
4257 times 981 times

GUO Jian Gulidanna·Asihaer ZHANG Shuyang

Rare disease Data collection Data management Digital intelligence
Details
Study on the method of using attention mechanism and meta-learning to diagnose autism under small sample multi-omics condition

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):887-896.
4252 times 1005 times

WANG Qi XIE Kun LIANG Xuezhi LUO Xiangyang LIU Ying CHEN Wen

Autism diagnosis Attention mechanism Meta learning Small sample Multi-omics data integration
Details
Cognitive trajectories modeling of rare reversion in mild cognitive impairment

Published on Chinese Journal of Pharmacoepidemiology 2025,34(8):877-886.
4624 times 1108 times

QIN Yao HUO Yanji ZHOU Jing ZHOU Yan HAN Hongjuan CUI Jing YU Hongmei

Mild cognitive impairment Reversion Rare events Functional principal component analysis Multi-state model
Details