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Expert consensus for off-label drug use of rare diseases (2026 edition)

Published on Chinese Journal of Pharmacoepidemiology 2026,35(5):493-507.
5385 times 1538 times

DUAN Yuehan CHEN Chaoyang ZHANG Yu CUI Yi-min WANG Shengfeng DING Jie Working Group of the Expert Consensus for Off-Label Drug Use of Rare Diseases

Rare disease Off-label drug use Expert consensus Thomson evidence grading system
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Guide on Methodological Standards in Pharmacoepidemiology (2nd edition) and their series interpretation (17): application of predictive models in drug effectiveness and safety evaluation

Published on Chinese Journal of Pharmacoepidemiology 2026,35(5):481-492.
4730 times 1365 times

NIE Xiaolu WU Yunxiao ZHAO Houyu ZHAN Siyan SUN Feng

Predictive models Pharmacoepidemiology Precision Medicine Ef-fectiveness evaluation Safety evaluation Heterogeneity of treatment effects Biomarkers
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Klinefelter syndrome with diabetes ketoacidosis as the first manifestation: a case report and literature analysis

Published on Journal of Mathematical Medicine 2026,39(4):314-318.
4851 times 1280 times

LIU Xiaoyu YANG Fan WU Jing YIN Wanling

Klinefelter syndrome Hypogonadism Gynecomastia Diabetic ketoacidosis Osteoporosis
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Fertility-sparing treatment for ovarian yolk sac tumor in a woman of childbearing age: a case report

Published on Journal of Mathematical Medicine 2026,39(4):307-313.
7339 times 1315 times

HE Li CHEN Yuyan WEI Yi ZHANG Fan

Ovarian yolk sac tumor Ovarian malignant germ cell tumor Childbearing age Fertility-sparing treatment
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Hemostatic management during the perioperative period in a patient with severe hemophilia A and high-titer FⅧ inhibitors: a case report

Published on Journal of Mathematical Medicine 2026,39(4):301-306.
4847 times 1142 times

WANG Ziqing ZHANG Xian

Hemophilia A Factor Ⅷ inhibitor Recombinant activated factor Ⅶ Os-teofascial Compartment syndrome
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Research progress of traditional Chinese medicine on the regulation of Notch signaling pathway in the treatment of rheumatoid arthritis

Published on Journal of Mathematical Medicine 2026,39(4):294-300.
5901 times 1168 times

LI Mingxia CHEN Junlong HE Bianqiang HE Wenkui GAO Wanpeng

Rheumatoid arthritis Notch signaling pathway Traditional Chinese medicine Mechanism
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Influencing factors of healthcare-seeking delay for pulmonary tuberculosis pa-tients in China from 2014 to 2024: a Meta-analysis

Published on Journal of Mathematical Medicine 2026,39(4):282-293.
5239 times 1064 times

HUANG Chen AN Xuemei YANG Tingyu HONG Zhongxi LUO Yongyuan XIONG Xiya ZHOU Xianyu

Tuberculosis Healthcare-seeking delay Influencing factors Meta-analysis
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Efficacy analysis of extended curettage combined with denosumab adjuvant therapy for giant cell tumor of the bone

Published on Journal of Mathematical Medicine 2026,39(4):273-281.
5675 times 1132 times

WEN Riyou LE Guoping

Giant cell tumor of the bone Extended curettage Denosumab Relapse rate
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A study on the mechanisms regulation of BIRC5 expression in prostate cancer and its potential targeted therapy

Published on Journal of Mathematical Medicine 2026,39(4):263-272.
4223 times 1055 times

YE Junjie CHEN Yunyi HUANG Yingxin LI Yanliang WANG Huifeng

Carcinoma of prostate BIRC5 gene Targeted therapy Mechanism
Details
SERPINE1 affects the metastasis of colon cancer by regulating MMP-9 and MMP-2

Published on Journal of Mathematical Medicine 2026,39(4):252-262.
4032 times 959 times

CHEN Dehe DING Pengpeng LI Wending LI Hongtao

Colon cancer SERPINE1 MMP-9 MMP-2 Metastasis
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Bibliometric analysis of the research status, hotspots and trends in the field of prescription comment in China

Published on Journal of Mathematical Medicine 2026,39(4):241-251.
4835 times 1203 times

YUAN Jiachen YU Lu CHEN Yuqin

Prescription comment Bibliometrics CiteSpace VOSviewer Hotspots Trends
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Discussion on the field practice teaching mode of medicinal botany based on the orientation of scientific research innovation practice

Published on Frontiers in Pharmaceutical Sciences 2026,30(4):715-720.
3304 times 733 times

CHEN Peng PENG Yansong CHEN Fuchao HE Jingsheng ZOU Youquan TANG Jun LIU Gang ZHOU Benhong

Medicinal botany Field practice Innovative practice Digital intelligence technology Ethnic medicine Teaching assessment Talent cultivation
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Design and application scenarios of digital monitoring model for online drug sales——based on Shanghai online drug circulation supervision system

Published on Frontiers in Pharmaceutical Sciences 2026,30(4):707-714.
3493 times 943 times

ZHUANG Wenyi ZHAO Yuxiang FENG Xiao SHEN Kan WANG Haibo GUO Aiwei ZHOU Fengwu WANG Guangping

Drug Online Circulation Digitalization Monitoring Robotic process automation Case Investigation and Handling Database
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Research progress on the relationship between vitamin D and pediatric sepsis

Published on Frontiers in Pharmaceutical Sciences 2026,30(4):699-706.
3400 times 885 times

ZHU Liran XIA Wenwen WANG Zhen CUI Wei CAI Ming LIU Haipeng

Pediatric sepsis Vitamin D 25-hydroxyvitamin D3 Immune regulation Inflammatory response Clinical outcomey
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Research progress on the hepatoprotective effects and safety evaluation of sophocarpine

Published on Frontiers in Pharmaceutical Sciences 2026,30(4):692-698.
3228 times 886 times

JIANG Jingjing WANG Changlin SONG Chunhong LI Yanan

Sophocarpine Hepatoprotective effect Safety evaluation Lipid metabolism An-ti-fibrosis Anti-inflammatory Anti-tumor Hepatotoxicity Acute toxicity
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Research progress on therapeutic strategies and mechanisms of action of traditional Chinese medicines with “medicine-food homology” in the prevention and treatment of chemo-therapy-induced myelosuppression

Published on Frontiers in Pharmaceutical Sciences 2026,30(4):679-691.
4648 times 1022 times

CHEN Weishi LI Jing LI Jing HAN Tao

Chemotherapy-induced myelosuppression Medicine-food homology Etiology and pathogenesis Treatment strategies Characteristics of traditional Chinese medicine Active ingredients Mechanism of action Medullary hematopoiesis
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Research progress on chemical components and pharmacological effects of Anisi Stellati Fructus

Published on Frontiers in Pharmaceutical Sciences 2026,30(4):668-678.
7505 times 1522 times

YU Ran DI Qing SUN Guyue ZHAO Xiangxuan

Anisi Stellati Fructus Chemical components Pharmacological effect Immune regulation Antioxidation Flavonoids Antibacterial Antitumor
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Investigation and analysis on the current status of high-alert medications management and pharmacists’ cognition in medical institutions in Hubei Province

Published on Frontiers in Pharmaceutical Sciences 2026,30(4):657-667.
3277 times 888 times

RONG Xinyi LI Wei ZHANG Chengliang YU Zaoqin

High-alert medications Pharmacist Management status Cognitive level Influencing factors
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Adverse event signal mining and analysis of tucatinib based on the FAERS database

Published on Frontiers in Pharmaceutical Sciences 2026,30(4):649-656.
3527 times 1024 times

ZHAO Jun ZHAO Zhenying WANG Meisa LI Weiya JIANG Yuan YANG Fengkun

Tucatinib Breast cancer HER2 inhibitor FAERS database Adverse event Disproportionality method
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Visualization analysis on research progress and trends of Radix Bupleuri

Published on Frontiers in Pharmaceutical Sciences 2026,30(4):639-648.
4252 times 972 times

ZHANG Xiuna FANG Jing TIAN Hui ZHAO Chaoyue YANG Yidi QU Fanna

Chinese medicinal materials Radix Bupleuri Bibliometrics Visualization analysis CiteSpace Network pharmacology Quality control
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