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A total of 80 result was found. Results that relate to Signal

Application of valsartan in combination with amlodipine in adverse reactions in elderly patients with hypertension

Published on Frontiers in Pharmaceutical Sciences 2025,29(11):1906-1913.
3395 times 550 times

ZHOU Yan SU Fei ZHU Junjun LYU Xiongsheng

Valsartan Amlodipine Hypertension Elderly FAERS database Adverse drug event Rational drug use Signal mining
Details
Signal mining and analysis of drug-related thrombocytopenia based on FAERS database

Published on Chinese Journal of Pharmacoepidemiology 2025,34(12):1382-1389.
2709 times 548 times

ZHOU Guowei ZHANG Hongyan JIAO Yanyan QUAN Xianghua

Thrombocytopenia Adverse drug events FAERS database Pharmacovigilance Signal mining
Details
Signal mining and sex-specific subgroup analysis of donepezil-associated adverse events based on the FAERS database

Published on Chinese Journal of Pharmacoepidemiology 2026,35(1):51-61.
2095 times 488 times

NING Siming SUN Bao ZOU Hao QI Fengyu YANG Ruixia QIAO Yi

Donepezil FAERS database Adverse drug event Signal mining
Details
Integrated network pharmacology and molecular docking to explore the potential molecular mechanisms of diosmin against prostatic hyperplasia complicated with chronic prostatitis

Published on Frontiers in Pharmaceutical Sciences 2025,29(12):1981-1989.
2322 times 471 times

TANG Liu JIANG Xiao LUO Guangwen WANG Lei

Diosmin Benign prostatic hyperplasia Chronic prostatitis Network pharmacology Molecular docking Signaling pathway GO funnction analysis KEGG pathway analysis
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Exploring the effect of astragalus polysaccharides on adriamycin-induced apoptosis of AC16 cardiomyocytes based on the TGF-β1/Smad3 signaling pathway

Published on Frontiers in Pharmaceutical Sciences 2025,29(12):2009-2016.
1938 times 393 times

WANG Dui DANG Lijuan ZHANG Qiang ZHAO Xiaobin LI Xiaoyu ZHANG Zhengfeng

Astragalus polysaccharides Doxorubicin Myocardial injury TGF-β1/Smad3 signaling pathway Traditional Chinese medicine AC16 Cardiomyocytes Apoptosis
Details
Construction of a shortage risk early warning model based on risk matrix evaluation and Bayesian belief propagation neural network

Published on Frontiers in Pharmaceutical Sciences 2025,29(12):2027-2035.
1989 times 377 times

SUN Yiyuan LIU Junjiao NI Ying LIANG Liangliang LIU Yunmei ZHAO Guohong ZHANG Jingbo YANG Yang LI Qiang

Drug shortage Drug use monitoring Risk warning Signal detection Bayesian confidence propagation neural network
Details
Effective analysis of adverse drug events and toxicological mechanisms of octreotide based on the FAERS database and network toxicology

Published on Frontiers in Pharmaceutical Sciences 2025,29(12):2036-2045.
2089 times 411 times

WANG Changwen WANG Huiru XU Shibo SUN Fanfan YAN Junzhen

Octreotide Adverse drug events Network toxicology Signal mining FAERS Tumor necrosis factor Ransforming growth factor β Protein-protein interaction
Details
Pharmacovigilance analysis of drug-related extrapyramidal symptoms based on the FAERS database

Published on Frontiers in Pharmaceutical Sciences 2025,29(12):2056-2064.
2004 times 483 times

WU Lihua WANG Huiying CHEN Yangyi PAN Lu RAO Mei

Drug related extrapyramidal symptoms Adverse drug reactions Pharmacovigilance Signal Mining FAERS database Logistic regression
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Research progress in the treatment of simple obesity with traditional Chinese medicine compounds

Published on Frontiers in Pharmaceutical Sciences 2025,29(12):2137-2144.
2734 times 376 times

ZHANG Xiali WANG Zhuo MI Li

Simple obesity Traditional Chinese medicine compounding Research progress Leptin resistance Insulin resistance Gut microbiota dysbiosis JAK2-STAT3 signaling pathway PI3K/Akt signaling pathway
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Adverse drug event signal mining of ezetimibe monotherapy and compound preparations based on the FAERS database

Published on Chinese Journal of Pharmacoepidemiology 2026,35(2):156-163.
1830 times 426 times

HUANG Yan YU Yang

Ezetimibe Single tablet compound preparation containing ezetimibe Combination therapy Adverse drug event Signal mining Pharmacovigilance
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Post-authorisation safety evaluation of extracorporeal blood circuit based on literature and MAUDE database

Published on Chinese Journal of Pharmacoepidemiology 2026,35(2):173-181.
1116 times 315 times

LI Kaili ZENG Baoqi HUANG Ling WANG Qiping SUN Feng

Extracorporeal blood circuit Adverse events Literature search Signal detection Product quality Connection problems Operational technique
Details
Exploring the in vitro anti-tumor effect and mechanism of Rumex chalepensis based on network pharmacology

Published on Frontiers in Pharmaceutical Sciences 2026,30(1):2-11.
1543 times 342 times

GUO Changhong YAN Guangjun MIAO Qing LIU Limei XU Jing LIU Chong WANG Yejing XIANG Caiqiong

Rumex chalepensis Network pharmacology Gastric cancer PI3K/Akt signaling pathway Apoptosis Cell cycle arrest Multi-target action Natural anti-tumor drug
Details
Analysis of adverse events associated with cetuximab based on the FAERS database

Published on Frontiers in Pharmaceutical Sciences 2026,30(1):87-97.
1693 times 290 times

RUI Wenyue LIU Jiahui QIAO Qian CHEN Zhaofeng LIU Min

Cetuximab FAERS Database Adverse events Pharmacovigilance Signal mining Bayesian confidence propagation neural network Proportional report ratio Drug-drug interactions
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Network pharmacological exploration of the mechanism of Scutellaria baicalensis antigenic primary biliary cholangitis

Published on Frontiers in Pharmaceutical Sciences 2026,30(2):181-189.
1239 times 282 times

WANG Chunxia ZHAO Zan GUO Qinghong

Primary biliary cholangitis Scutellaria baicalensis Network pharmacology Molecular docking Molecular dynamics simulation Signaling pathways GO function analysis KEGG pathway enrichment analysis
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Exploring the mechanism of action of Aconitum Heterophyllum in treating gout based on network pharmacology and molecular modeling

Published on Frontiers in Pharmaceutical Sciences 2026,30(2):190-200.
1270 times 258 times

ZHANG Ruirui CHEN Quansheng ZHANG Bingyin WU Yuwen YAN Caifeng

Aconitum Heterophyllum Gout Network pharmacology Molecular docking Molecular dynamics simulation Active ingredients Signaling pathways Protein-protein interactions
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